You can’t stay logged in to Manuscript. You log in, as soon as you click on something you are prompted to log in again.
1. Cookie handling: Instruct your browser to accept cookies. This is the default setting in IE, so restoring IE to defaults should do this right off the bat. In IE there are various approaches:
View > Internet Options > Privacy tab > Advanced > select Accept
Or Privacy Tab > Edit (Web Sites) > add your Manuscript server to the Allow list
More (three vertical dots) > Settings > Advanced. Under “Privacy and security” > Content settings > Cookies select “Allow sites to save and read cookie data”
Also note that the way cookies work, URLs are considered case sensitive for the purpose of setting cookies. If you have logged onto http://example.com/Manuscript, you will not be logged onto http://example.com/manuscript because the capitalization of Manuscript differs.
2. Database permissions (Licensed Manuscript problem only): The database login that Manuscript uses must be the db owner for the Manuscript database. If it isn’t, this problem will occur (or you will get an error message).
A recent problem where no POST variables are accepted by IIS can cause this too. To check this, create a test.asp file with the following in it inside the Manuscript website directory:
<% Response.Write Request("foo") %> <form method="POST"> <input type="text" name="foo" /> <input type="submit"> </form>
Load this page in a browser and type some text and hit submit. If nothing appears, please see this MSFT KB article which describes problems with Windows Authentication.